PCL-PEG-SH, MW x 1K, n 1K is a thiol-functionalized amphiphilic block copolymer composed of poly(ε-caprolactone) (PCL) and polyethylene glycol (PEG). This grade combines approximately 1K PCL with 1K PEG, providing balanced hydrophobic and hydrophilic segments, while the terminal thiol enables conjugation and surface functionalization.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and drug delivery.
- PCL MW 1K: Provides a short biodegradable hydrophobic segment for polymer assembly and hydrophobic interactions.
- PEG MW 1K: Provides a hydrophilic segment specifically for aqueous compatibility and interfacial stabilization.
- Balanced Block Ratio: Equal PCL and PEG molecular weights provide balanced hydrophobic and hydrophilic character.
- Thiol Functionalization: Provides a terminal sulfhydryl (-SH) group specifically for conjugation and surface modification.
- Versatile Reactivity: The terminal thiol reacts with maleimides and other thiol-reactive functional groups under suitable conditions.
Applications
- Bioconjugation: Enables coupling with maleimide-functionalized peptides, proteins, ligands, and other molecules.
- Nanoparticle Functionalization: Supports functionalized nanoparticles, micelles, and amphiphilic polymer assemblies.
- Drug Delivery: Supports polymeric carriers for hydrophobic compounds and functionalized delivery systems.
- Surface Functionalization: Terminal thiol enables attachment to compatible thiol-reactive surfaces and materials.
- Crosslinking Research: Supports preparation of functional polymer networks using thiol-reactive chemistry.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture, heat, and oxidizing conditions. Thiol groups can oxidize to form disulfides.
PCL-PEG-SH, MW x 1K, n 1K combines balanced PCL and PEG blocks with terminal thiol functionality and specifically supports amphiphilic assembly, bioconjugation, drug delivery, and surface functionalization.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.