PCL-PEG-SH, MW x 10K, n 5K is a thiol-functionalized amphiphilic block copolymer. It combines a 10K poly(ε-caprolactone) (PCL) block with a 5K polyethylene glycol (PEG) block. The PCL segment supports hydrophobic assembly and drug incorporation, while the terminal thiol enables conjugation with thiol-reactive molecules and surfaces.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and drug delivery.
- PCL MW 10K: Provides a biodegradable hydrophobic block for core formation and hydrophobic compound incorporation.
- PEG MW 5K: Provides a hydrophilic segment specifically for aqueous compatibility and steric stabilization.
- PCL-Rich Architecture: The 2:1 PCL-to-PEG molecular weight ratio favors hydrophobic interactions and core-forming assemblies.
- Thiol Functionalization: Provides a terminal sulfhydryl group for conjugation and surface modification.
- Versatile Reactivity: The thiol can react with maleimides, haloacetyl groups, and other thiol-reactive functionalities.
Applications
- Bioconjugation: Enables coupling with maleimide-functionalized peptides, proteins, ligands, and other molecules.
- Nanoparticle Functionalization: Supports functionalized nanoparticles, micelles, and other amphiphilic polymer assemblies.
- Drug Delivery: Supports polymeric carriers specifically for hydrophobic compounds and targeted delivery research.
- Surface Functionalization: Terminal thiol supports attachment to compatible thiol-reactive surfaces and materials.
- Crosslinking Research: Supports preparation of thiol-reactive networks and functional polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture, heat, and oxidizing conditions. Thiol groups can oxidize to form disulfides.
PCL-PEG-SH, MW x 10K, n 5K combines biodegradable PCL with hydrophilic PEG and terminal thiol functionality and specifically supports bioconjugation, nanoparticle functionalization, drug delivery, and surface modification.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.