PCL-PEG-N3, MW x 3K, n 1K is an azide-functionalized amphiphilic block copolymer containing poly(ε-caprolactone), polyethylene glycol, and a terminal azide group. This grade combines approximately 3K PCL with 1K PEG and its PCL-rich architecture favors hydrophobic assembly, while the azide enables selective click conjugation.
Key Features and Benefits
- Amphiphilic Copolymer: Combines a dominant hydrophobic PCL block with a short hydrophilic PEG segment.
- PCL MW 3K: Provides a biodegradable hydrophobic segment for core formation and hydrophobic drug incorporation.
- PEG MW 1K: Provides a short hydrophilic segment specifically for interfacial stabilization and surface functionality.
- PCL-Rich Architecture: The 3:1 PCL-to-PEG ratio favors hydrophobic interactions and core-forming behavior.
- Azide Functionalization: Provides a terminal azide group for selective click chemistry reactions.
- Click Chemistry: Supports CuAAC with terminal alkynes and SPAAC with strained cyclooctynes.
Applications
- Click Conjugation: Enables attachment of compatible alkyne- and cyclooctyne-functionalized molecules.
- Nanoparticle Research: Supports clickable nanoparticles, micelles, and amphiphilic polymer assemblies.
- Drug Delivery: Supports polymeric carriers for hydrophobic compounds and controlled-delivery research.
- Ligand Attachment: Enables conjugation of targeting ligands, peptides, probes, and compatible biomolecules.
- Biomaterial Research: Supports development of click-functionalized and biodegradable polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat to maintain polymer integrity and azide functionality.
PCL-PEG-N3, MW x 3K, n 1K combines a dominant PCL block with short PEG and terminal azide functionality that specifically supports hydrophobic polymer assemblies, click conjugation, drug delivery, and functional biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.