PCL-PEG-N3, MW x 5K, n 5K is an azide-functionalized amphiphilic block copolymer containing poly(ε-caprolactone), polyethylene glycol, and a terminal azide group. This grade combines approximately 5K PCL with 5K PEG and its balanced block architecture supports amphiphilic assembly, while the azide enables selective click conjugation.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and drug delivery.
- PCL MW 5K: Provides a biodegradable hydrophobic segment for core formation and hydrophobic drug incorporation.
- PEG MW 5K: Provides a hydrophilic segment for aqueous compatibility and steric stabilization.
- Balanced Block Ratio: Equal PCL and PEG molecular weights specifically provide balanced hydrophobic and hydrophilic character.
- Azide Functionalization: Provides a terminal azide group for selective click chemistry reactions.
- Click Chemistry: Supports CuAAC with terminal alkynes and SPAAC with strained cyclooctynes.
Applications
- Click Conjugation: Enables attachment of compatible alkyne- and cyclooctyne-functionalized molecules.
- Nanoparticle Research: Supports clickable nanoparticles, micelles, and amphiphilic polymer assemblies.
- Drug Delivery: Supports polymeric carriers for hydrophobic compounds and targeted delivery research.
- Ligand Attachment: Enables conjugation of targeting ligands, peptides, probes, and compatible biomolecules.
- Biomaterial Research: Supports development of click-functionalized and biodegradable polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat to maintain polymer integrity and azide functionality.
PCL-PEG-N3, MW x 5K, n 5K combines balanced PCL and PEG blocks with terminal azide functionality that specifically supports amphiphilic assembly, click conjugation, drug delivery, and functional biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.