PCL-PEG-N3, MW x 2K, n 3K is an azide-functionalized amphiphilic block copolymer containing poly(ε-caprolactone), polyethylene glycol, and a terminal azide group. This grade combines approximately 2K PCL with 3K PEG and its PEG-rich architecture supports hydrophilic stabilization, while the azide enables selective click conjugation.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and drug delivery.
- PCL MW 2K: Provides a biodegradable hydrophobic segment for core formation and hydrophobic drug incorporation.
- PEG MW 3K: Provides a hydrophilic segment specifically for aqueous compatibility and steric stabilization.
- PEG-Rich Architecture: The 3:2 PEG-to-PCL ratio favors hydrophilic character and surface stabilization.
- Azide Functionalization: Provides a terminal azide group for selective click chemistry reactions.
- Click Chemistry: Supports CuAAC with terminal alkynes and SPAAC with strained cyclooctynes.
Applications
- Click Conjugation: Enables attachment of compatible alkyne- and cyclooctyne-functionalized molecules.
- Nanoparticle Functionalization: Supports clickable nanoparticles, micelles, and PEG-stabilized nanocarriers.
- Drug Delivery: Supports functionalized carriers for hydrophobic compounds and targeted delivery research.
- Ligand Attachment: Enables conjugation of targeting ligands, peptides, probes, and compatible biomolecules.
- Biomaterial Research: Supports development of click-functionalized and biodegradable polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat to maintain polymer integrity and azide functionality.
PCL-PEG-N3, MW x 2K, n 3K combines biodegradable PCL with a longer PEG segment and terminal azide functionality that specifically supports stabilized polymer assemblies, click conjugation, drug delivery, and functional biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.