PCL-PEG-N3, MW x 1K, n 2K is an azide-functionalized amphiphilic block copolymer containing poly(ε-caprolactone), polyethylene glycol, and a terminal azide group. This grade combines approximately 1K PCL with 2K PEG and its PEG-rich architecture supports hydrophilic stabilization, while the azide enables selective click conjugation.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and drug delivery.
- PCL MW 1K: Provides a short biodegradable hydrophobic segment for polymer assembly and hydrophobic interactions.
- PEG MW 2K: Provides a longer hydrophilic segment specifically for aqueous compatibility and steric stabilization.
- PEG-Rich Architecture: The 2:1 PEG-to-PCL ratio favors hydrophilic character and surface stabilization.
- Azide Functionalization: Provides a terminal azide group for selective click chemistry reactions.
- Click Chemistry: Supports CuAAC with terminal alkynes and SPAAC with strained cyclooctynes.
Applications
- Click Conjugation: Enables attachment of compatible alkyne- and cyclooctyne-functionalized molecules.
- Nanoparticle Functionalization: Supports clickable nanoparticles, micelles, and PEG-stabilized nanocarriers.
- Drug Delivery: Supports functionalized amphiphilic carriers and targeted drug delivery research.
- Ligand Attachment: Enables conjugation of targeting ligands, peptides, probes, and compatible biomolecules.
- Biomaterial Research: Supports development of click-functionalized and biodegradable polymer systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat to maintain polymer integrity and azide functionality.
PCL-PEG-N3, MW x 1K, n 2K combines a short PCL block with a longer PEG segment and terminal azide functionality that specifically supports hydrophilic stabilization, click conjugation, functionalized nanocarriers, and drug delivery research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.