PCL-PEG-COOH, MW x 10K, n 5K is a carboxyl-functionalized amphiphilic block copolymer composed of poly(ε-caprolactone) (PCL) and polyethylene glycol (PEG). This grade combines approximately 10K PCL with 5K PEG, providing a PCL-rich architecture for hydrophobic assembly and drug incorporation, while the terminal carboxyl group enables covalent conjugation and surface functionalization.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and drug delivery.
- PCL MW 10K: Provides a biodegradable hydrophobic block for core formation and incorporation of hydrophobic compounds.
- PEG MW 5K: Provides a hydrophilic segment specifically for aqueous compatibility and steric stabilization.
- PCL-Rich Architecture: The 2:1 PCL-to-PEG molecular weight ratio favors hydrophobic interactions and core-forming assemblies.
- Carboxyl Functionalization: Provides a terminal carboxyl (-COOH) group for conjugation and further chemical modification.
- Amine Coupling: The carboxyl group can be activated using carbodiimide chemistry, such as EDC/NHS, for coupling with primary amines to form stable amide bonds.
Applications
- Bioconjugation: Enables attachment of amine-containing peptides, proteins, ligands, and other biomolecules.
- Nanoparticle Functionalization: Supports surface-functionalized nanoparticles, micelles, and amphiphilic polymer assemblies.
- Drug Delivery: Supports polymeric carriers for hydrophobic compounds and targeted delivery research.
- Ligand Conjugation: Enables covalent attachment of amine-containing targeting ligands through carboxyl activation chemistry.
- Biomaterial Research: Supports development of functionalized biodegradable polymers and surface-modified biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. For conjugation, activate the terminal carboxyl group under appropriate reaction conditions.
PCL-PEG-COOH, MW x 10K, n 5K combines a PCL-rich amphiphilic architecture with terminal carboxyl functionality and specifically supports amine coupling, nanoparticle functionalization, targeted drug delivery, and biomaterial development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.