PCL-PEG-COOH, MW x 4K, n 5K is a carboxyl-functionalized amphiphilic block copolymer composed of poly(ε-caprolactone) (PCL) and polyethylene glycol (PEG). This grade combines approximately 4K PCL with 5K PEG, providing a slightly PEG-rich architecture for aqueous stabilization and polymer assembly, while the terminal carboxyl group enables covalent conjugation and surface functionalization.
Key Features and Benefits
- Amphiphilic Copolymer: Combines hydrophobic PCL with hydrophilic PEG for polymer assembly and drug delivery.
- PCL MW 4K: Provides a biodegradable hydrophobic segment for core formation and incorporation of hydrophobic compounds.
- PEG MW 5K: Provides a hydrophilic segment specifically for aqueous compatibility and steric stabilization.
- PEG-Rich Architecture: The 5:4 PEG-to-PCL molecular weight ratio provides increased hydrophilic character and surface stabilization.
- Carboxyl Functionalization: Provides a terminal carboxyl (-COOH) group for conjugation and further chemical modification.
- Amine Coupling: The carboxyl group can be activated using EDC/NHS chemistry for coupling with primary amines to form stable amide bonds.
Applications
- Bioconjugation: Enables attachment of amine-containing peptides, proteins, ligands, and other biomolecules.
- Nanoparticle Functionalization: Supports surface-functionalized nanoparticles, micelles, and PEG-stabilized polymer assemblies.
- Drug Delivery: Supports amphiphilic polymeric carriers specifically for hydrophobic compounds and targeted delivery research.
- Ligand Conjugation: Enables covalent attachment of amine-containing targeting ligands through carboxyl activation chemistry.
- Biomaterial Research: Supports development of functionalized biodegradable polymers and surface-modified biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. For conjugation, activate the terminal carboxyl group under appropriate reaction conditions.
PCL-PEG-COOH, MW x 4K, n 5K combines biodegradable PCL with a slightly longer PEG block and terminal carboxyl functionality and specifically supports stabilized polymer assemblies, amine coupling, drug delivery, and biomaterial functionalization.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.