pAsp-PEG-pAsp, MW x 1.15K, n 5K is a triblock copolymer composed of poly(L-aspartic acid) (pAsp) and polyethylene glycol (PEG), with pAsp blocks positioned on both sides of the central PEG segment. This grade combines approximately 1.15K pAsp with 5K PEG, providing an especially strong PEG-rich architecture with multiple carboxyl groups for chemical modification, molecular interactions, drug delivery, and biomaterial development.
Key Features and Benefits
- Triblock Copolymer Architecture: Combines two pAsp segments with a central PEG block to provide a functional pAsp-PEG-pAsp polymer platform.
- pAsp MW 1.15K: Provides carboxyl-rich poly(amino acid) segments with functional groups for molecular interactions and chemical modification.
- PEG MW 5K: Provides a substantial hydrophilic central segment that specifically contributes flexibility, hydration, and aqueous compatibility.
- PEG-Rich Architecture: The approximately 1:4.3 pAsp-to-PEG molecular weight ratio strongly favors hydrophilic PEG character while retaining functional carboxyl-rich pAsp segments.
- Carboxyl-Rich Polymer: The pAsp blocks provide pendant carboxyl groups for conjugation, ionic interactions, and further chemical functionalization.
- Functionalizable Polymer Platform: Supports modification of pAsp carboxyl groups with amine-containing molecules through coupling strategies such as EDC/NHS chemistry.
- Poly(amino acid)-PEG Design: Combines functional poly(amino acid) segments with PEG for development of advanced polymeric and biomaterial systems.
Applications
- Polymer Functionalization: Provides carboxyl groups for chemical modification and attachment of suitable functional molecules.
- Bioconjugation: Supports coupling with amine-containing peptides, proteins, targeting ligands, and other molecules through carboxyl-group chemistry.
- Drug Delivery: Supports development of functional polymer-based drug delivery and carrier systems.
- Ionic Complex Formation: The carboxyl-containing pAsp segments can participate in electrostatic interactions with positively charged molecules and ions.
- Hydrogel Development: Supports development of crosslinked polymer networks and functional hydrogel systems through appropriate modification or crosslinking strategies.
- Surface Modification: Supports functionalization of nanoparticles, coatings, and other biomaterial surfaces.
- Biomaterial Research: Supports development of functional poly(amino acid)-PEG materials, conjugates, polymer networks, and advanced biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product combines functional pAsp blocks with a substantial hydrophilic PEG segment in an especially strong PEG-rich triblock architecture. It specifically supports polymer functionalization, bioconjugation, drug delivery, ionic complex formation, hydrogel development, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
