mPEG-Poly(L-Aspartic Acid) (mPEG-pAsp), MW x 5K, n 5K is a functional block copolymer composed of methoxy polyethylene glycol (mPEG) and poly(L-aspartic acid) (pAsp). This grade combines approximately 5K mPEG with 5K pAsp, providing a balanced block architecture with a hydrophilic PEG segment and abundant carboxyl groups specifically for chemical modification, molecular interactions, drug delivery, and biomaterial development.
Key Features and Benefits
- Functional Block Copolymer: Combines hydrophilic mPEG with carboxyl-rich pAsp for drug delivery, bioconjugation, and biomaterial development.
- mPEG MW 5K: Provides a hydrophilic segment for aqueous compatibility, hydration, and steric stabilization.\
- pAsp MW 5K: Provides a poly(amino acid) segment with multiple pendant carboxyl groups for molecular interactions and chemical modification.
- Balanced Block Ratio: Equal mPEG and pAsp molecular weights provide balanced hydrophilic PEG character and carboxyl-rich pAsp functionality.
- Carboxyl-Rich Polymer: The pAsp segment provides multiple pendant carboxyl groups for conjugation, ionic interactions, and further chemical functionalization.
- Methoxy-Terminated PEG: The nonreactive methoxy end group provides a stable PEG terminus while the pAsp segment supplies functional sites for modification.
- Functionalizable Polymer Platform: Supports modification of pAsp carboxyl groups with amine-containing molecules through coupling strategies such as EDC/NHS chemistry.
Applications
- Polymer Functionalization: Provides multiple carboxyl groups for chemical modification and attachment of suitable functional molecules.
- Bioconjugation: Supports coupling with amine-containing peptides, proteins, targeting ligands, and other molecules through carboxyl-group chemistry.
- Drug Delivery: Supports development of functional polymer-based drug delivery and carrier systems.
- Ionic Complex Formation: The carboxyl-rich pAsp segment can participate in electrostatic interactions with positively charged molecules and ions.
- Surface Modification: Supports functionalization of nanoparticles, coatings, and other biomaterial surfaces.
- Polymer Conjugates: Supports development of functional polymer-drug, polymer-peptide, and other molecular conjugates.
- Biomaterial Research: Supports development of functional poly(amino acid)-PEG materials, conjugates, delivery systems, and advanced biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product combines hydrophilic mPEG with carboxyl-rich pAsp in a balanced block copolymer architecture. It specifically supports polymer functionalization, bioconjugation, drug delivery, ionic complex formation, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
