mPEG-Poly(L-Aspartic Acid) (mPEG-pAsp), MW x 3K, n 5K is a functional block copolymer composed of methoxy polyethylene glycol (mPEG) and poly(L-aspartic acid) (pAsp). This grade combines approximately 3K mPEG with 5K pAsp, providing a pAsp-rich architecture with a hydrophilic PEG segment and abundant pendant carboxyl groups specifically for polymer functionalization, bioconjugation, drug delivery, and biomaterial research.
Key Features and Benefits
- Functional Block Copolymer: Combines hydrophilic mPEG with carboxyl-functional pAsp for polymer modification, conjugation, drug delivery, and biomaterial development.
- mPEG MW 3K: Provides a hydrophilic segment specifically for aqueous compatibility, hydration, and steric stabilization.
- pAsp MW 5K: Provides a substantial poly(amino acid) segment with pendant carboxyl groups for molecular interactions and chemical modification.
- pAsp-Rich Architecture: The 3:5 mPEG-to-pAsp molecular weight ratio provides greater carboxyl-functional pAsp content while retaining a substantial hydrophilic mPEG component.
- Carboxyl-Rich Polymer: The pAsp block provides abundant pendant carboxyl groups that specifically support ionic interactions and chemical conjugation.
- Methoxy-Terminated PEG: Provides a nonreactive methoxy PEG terminus while the pAsp block supplies functional sites for further modification.
- Functionalizable Polymer Platform: Enables modification of pAsp carboxyl groups and coupling with amine-containing molecules using established carboxyl activation chemistries such as EDC/NHS.
Applications
- Polymer Functionalization: Provides pendant carboxyl groups for chemical modification and attachment of functional molecules.
- Bioconjugation: Supports coupling with amine-containing peptides, proteins, ligands, and other biomolecules through activated carboxyl groups.
- Drug Delivery: Supports development of functional polymer systems for drug-delivery and carrier research.
- Ionic Complex Formation: Provides carboxyl-rich pAsp segments for electrostatic interactions with positively charged molecules and materials.
- Surface Modification: Supports attachment of functional molecules and development of modified polymeric surfaces.
- Polymer Conjugates: Enables preparation of PEG-poly(amino acid) conjugates with drugs, targeting ligands, peptides, and other functional molecules.
- Biomaterial Research: Supports development of functional hydrophilic polymers for biomaterials, coatings, conjugates, and related research.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
This product combines hydrophilic mPEG with a substantial carboxyl-functional pAsp block in a pAsp-rich architecture. It specifically supports polymer functionalization, bioconjugation, drug delivery, ionic complex formation, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
