p-SCN-Bn-Deferoxamine
This product is a high-purity bifunctional chelating agent featuring a para-isothiocyanatobenzyl (p-SCN-Bn) group for conjugation to primary amines and a deferoxamine (DFO) moiety for strong coordination with zirconium-89 (^89Zr) and other metal ions. This design specifically enables stable, site-specific labeling of antibodies, peptides, and other biomolecules for use in PET imaging, targeted radiotherapy, and diagnostic research.
Key Features and Benefits
-
p-SCN-Bn Group: Reacts selectively with amines to form stable thiourea bonds under mild conditions.
-
Deferoxamine Chelator: High-affinity binding to ^89Zr and other metals for in vivo stability.
-
Optimized Spacer: Maintains chelation efficiency while minimizing steric hindrance to biomolecules.
-
High Purity: Supplied at >95% purity for reproducible performance in radiolabeling.
-
Versatile Use: Suitable for antibodies, peptides, nanoparticles, and other targeting vectors.
Applications
-
PET Imaging: Conjugate to targeting molecules for ^89Zr-based immuno-PET.
-
Targeted Radiotherapy: Deliver therapeutic isotopes with high stability and specificity.
-
Biomolecule Labeling: Functionalize proteins, peptides, and nanoparticles for metal-based detection.
-
Theranostics: Combine diagnostic imaging and therapeutic delivery in a single platform.
Storage and Handling
-
Storage: Store at –20 °C, dry, and protected from light.
-
Handling: Dissolve in anhydrous solvents (e.g., DMSO) or aqueous buffers (pH 8–9) immediately before use to preserve reactivity.
This product combines an amine-reactive p-SCN-Bn group with a high-affinity DFO chelator, enabling stable ^89Zr radiolabeling of biomolecules specfically for PET imaging and theranostic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
