Norbornene-PEG4-acetic acid
This product is a high-purity PEG linker with a terminal norbornene for bioorthogonal click reactions and a carboxylic acid group for amide coupling, specifically connected by a PEG4 spacer for solubility and flexibility.
Key Features and Benefits
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Norbornene Group – Enables rapid, bioorthogonal inverse-electron-demand Diels–Alder (IEDDA) click reactions with tetrazines.
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Carboxylic Acid Group – Reactive site for amide bond formation with primary amines.
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PEG4 Spacer – Provides solubility, flexibility, and reduced steric hindrance in conjugates.
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High Purity – Suitable for drug delivery, click chemistry, and bioconjugation applications.
Applications
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Bioorthogonal labeling using tetrazine ligation
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Amide coupling to proteins, peptides, or antibodies
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Linker design for targeted therapeutics and antibody–drug conjugates
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Dual-functional probe and material surface modification
Storage & Handling
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Storage: Store at –20 °C, dry, and protected from light.
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Use: Dissolve in anhydrous solvents (e.g., DMF, DMSO). Avoid repeated freeze–thaw cycles.
This product provides a norbornene group for tetrazine click chemistry and a carboxyl group for amide coupling, connected by a PEG4 spacer specifically to ensure solubility, flexibility, and efficient bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
