Folate-PEG3-Azide: Targeted Reagent for Click Chemistry and Cellular Labeling
Product Overview
Folate-PEG3-Azide is a specialized compound designed for precise bioconjugation and cellular targeting applications. This reagent combines folate for targeted delivery, a polyethylene glycol (PEG) linker for improved solubility and flexibility, and an azide group for efficient click chemistry.
Key Features
- Folate Group: Provides specific targeting to folate receptors, which are overexpressed in various cancer cells and certain tissues, enabling selective delivery of conjugated molecules.
- PEG3 Spacer: The polyethylene glycol (PEG) linker enhances solubility, reduces non-specific binding, and increases the flexibility of the conjugated molecule.
- Azide Group: Facilitates efficient and copper-free click chemistry, allowing for straightforward and clean conjugation with alkyne-functionalized partners.
Applications
- Cellular Targeting: Ideal for creating targeted drug delivery systems and imaging agents that specifically bind to folate receptors, common in cancer research and targeted therapy.
- Click Chemistry: Enables efficient and specific bioconjugation using click chemistry, useful for labeling, tagging, and linking biomolecules.
- Biosensor Development: Useful in developing biosensors and assays where targeted interactions and precise labeling are required.
Benefits
- Selective Targeting: The folate group ensures targeted delivery to folate receptor-expressing cells, improving the specificity and effectiveness of the conjugated molecules.
- Enhanced Solubility: PEG3 spacer enhances solubility and reduces non-specific interactions, contributing to more accurate experimental results.
- Efficient Conjugation: The azide group supports copper-free click chemistry, providing a clean and reliable method for bioconjugation.
Conclusion
Folate-PEG3-Azide is an essential tool for researchers in targeted drug delivery, cellular labeling, and biosensor development. Its combination of folate targeting, PEG spacer, and azide for click chemistry makes it a versatile and effective reagent for precise biochemical applications. Enhance your research with Folate-PEG3-Azide for reliable, targeted, and efficient results.
Ref:
Folate-Targeted PEG as a Potential Carrier for Carboplatin Analogs. Synthesis and in Vitro Studies Olga Aronov, Aviva T. Horowitz, Alberto Gabizon, and Dan Gibson Bioconjugate Chemistry 2003 14 (3), 563-574 DOI: 10.1021/bc025642l
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
