Nε-Trifluoroacetyl-L-Lysine N-Carboxyanhydride (TFA-Lys-NCA) is a side-chain-protected L-lysine NCA monomer for polypeptide synthesis. Its trifluoroacetyl group protects the ε-amino group while supporting controlled ring-opening polymerization and subsequent functional polymer development.
Key Features and Benefits
- NCA Monomer: TFA-Lys-NCA provides a reactive amino acid N-carboxyanhydride monomer for polypeptide synthesis.
- L-Lysine Derivative: The monomer retains the L-lysine structure while protecting its side-chain amino functionality.
- Nε-Trifluoroacetyl Protection: The trifluoroacetyl group protects the ε-amino group during polymerization and subsequent synthetic steps.
- Ring-Opening Polymerization: Supports NCA ring-opening polymerization specifically for preparing lysine-containing polypeptides.
- Poly(L-Lysine) Precursor: Provides a protected monomer platform for synthesizing poly(L-lysine) and related copolypeptides.
- Side-Chain Deprotection: Removal of the trifluoroacetyl protecting groups can specifically expose pendant ε-amino groups for further modification.
- Amine Functionalization: Deprotected polymers provide reactive amino groups specifically for conjugation and polymer functionalization.
- Functional Polymer Platform: Supports development of functional polypeptides, block copolypeptides, and related biomaterials.
Applications
- Poly(L-Lysine) Synthesis: Researchers use TFA-Lys-NCA to prepare protected poly(L-lysine) through NCA ring-opening polymerization.
- NCA Polymerization: Supports controlled synthesis of polypeptide and copolypeptide architectures.
- Polypeptide Synthesis: Enables preparation of lysine-containing synthetic polypeptides with protected side-chain amino groups.
- Block Copolypeptide Research: Supports synthesis of block copolypeptides containing protected poly(L-lysine) segments.
- Amine-Functional Polymer Research: Deprotection provides pendant amino groups for subsequent conjugation and modification.
- Polymer Functionalization: Exposed ε-amino groups can support coupling with compatible amine-reactive molecules and functional groups.
- Biomaterial Research: Supports development of functional polypeptides and lysine-containing polymer systems for biomaterial research.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: NCA monomers are moisture sensitive. Handle under dry conditions and minimize exposure to atmospheric moisture before polymerization.
Nε-Trifluoroacetyl-L-Lysine N-Carboxyanhydride (TFA-Lys-NCA) provides a protected lysine monomer for NCA polymerization and specifically supports poly(L-lysine) synthesis, copolypeptide development, deprotection, and subsequent amine functionalization.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
