As the ultra‑high‑molecular‑weight flagship of the PCL‑N3 series, this 20 kDa azide‑terminated poly(ε‑caprolactone) features dense chain packing and maximum crystallinity, distinguishing it sharply from all lower‑molecular‑weight counterparts. Its terminal azide retains full bio‑orthogonal reactivity to perform CuAAC click cycloaddition, forming irreversible triazole linkages with alkyne‑functionalized peptides, growth factors and surface substrates. Driven by extensive chain entanglement, hydrolytic erosion slows to multi‑month timescales; physical structures can sustain implant‑relevant mechanical loads inside subcutaneous tissue environments. Unlike medium‑MW grades optimized for circulating nanoparticles, this polymer is engineered primarily for solid implant and scaffold workflows, where long‑term structural persistence and site‑specific post‑fabrication bio‑modification are central experimental goals.
Key Features: ‑ Ultra‑high‑molecular‑weight highly crystalline PCL backbone end‑capped with azide; dense chain entanglement delivers outstanding mechanical toughness for implant‑oriented polymer constructs ‑ Multi‑month ultra‑slow hydrolytic degradation profile; maintains complete structural integrity over prolonged in‑vivo implant cycles before gradual bulk matrix erosion proceeds ‑ Preserved azide bio‑orthogonality under biological conditions; no off‑target interactions with endogenous thiols, amines or hydroxyl groups, ensuring clean CuAAC click coupling ‑ Excellent processability for electrospinning and solvent casting; generates dimension‑resilient fibres and implant membranes resistant to deformation within tissue microenvironments ‑ Spectroscopically validated azide end‑group conversion; strictly controlled residual monomer and catalyst levels suited for advanced implant‑focused pre‑clinical laboratory research
Applications: ‑ Click‑functionalized electrospun implant scaffolds covalently decorated with alkyne‑tagged bioactive factors for long‑term tissue‑engineering research ‑ Fabrication of surface‑tunable solid polymer implant prototypes requiring multi‑month mechanical persistence and site‑specific biomolecule immobilization ‑ Development of local long‑acting drug‑release implant devices where carrier structural stability must persist across multiple‑month in‑vivo observation windows ‑ Assembly of triazole‑linked polymer‑biomolecule conjugates tailored for implant‑tissue interface remodelling, rather than intravenous circulating nanoparticle applications ‑ Pre‑screening of implant‑grade azide‑terminated polyesters for translational pre‑clinical research pipelines
Handling & Storage: Store lyophilized polymer powder at −20 °C under dry inert‑gas atmosphere. While azide groups exhibit greater hydrolytic stability compared to maleimide moieties, prolonged humidity exposure will still gradually diminish click‑chemistry performance. Keep sealed vials inside a desiccator and achieve full room‑temperature thermal equilibration before opening, to avoid water vapour condensation contaminating solid polymer samples. Prepare working solutions exclusively with anhydrous organic solvents right before experimental manipulation; do not archive pre‑dissolved polymer stock solutions. This material is for laboratory research only and has not been authorized for human clinical use.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.