N3-Poly(ε-caprolactone) (PCL-N3), MW 15K is an azide-functionalized poly(ε-caprolactone) with a molecular weight of approximately 15K. It combines a biodegradable PCL backbone with terminal azide functionality specifically for click chemistry, bioconjugation, polymer functionalization, nanoparticle modification, surface modification, and biomaterial research.
Key Features and Benefits
- Azide-Functionalized PCL: Combines biodegradable poly(ε-caprolactone) with a terminal azide group for selective chemical modification and conjugation.
- MW 15K: Provides an intermediate molecular weight that specifically balances polymer processability, material formation, and functionalization.
- Azide Functionality: The terminal –N3 group provides a reactive site for click chemistry with compatible alkyne-functionalized molecules and materials.
- Biodegradable Polyester: The PCL backbone contains hydrolyzable ester linkages that specifically support gradual polymer degradation under appropriate conditions.
- Semicrystalline PCL Backbone: The PCL structure specifically supports semicrystalline polymer formation and provides useful material-forming properties for biodegradable polymer research.
- Click Chemistry Platform: The azide terminus supports copper(I)-catalyzed azide-alkyne cycloaddition (CuAAC) with terminal alkyne-functionalized molecules.
- Copper-Free Conjugation: The azide group also supports strain-promoted azide-alkyne cycloaddition (SPAAC) with compatible strained cyclooctynes such as DBCO and BCN.
Applications
- CuAAC Click Chemistry: Supports copper(I)-catalyzed conjugation with terminal alkyne-functionalized molecules and materials.
- Copper-Free Click Chemistry: Enables SPAAC conjugation with DBCO, BCN, and other compatible strained cyclooctyne-functionalized compounds.
- Bioconjugation: Supports attachment of compatible biomolecules, peptides, proteins, ligands, probes, and other functional components.
- Polymer Functionalization: Enables preparation of functional PCL derivatives, block copolymers, and more complex polymer architectures.
- Nanoparticle Functionalization: Supports functionalization of biodegradable polymer nanoparticles and related delivery systems.
- Surface Modification: Enables click-based modification of PCL-containing surfaces, coatings, and materials.
- Drug Delivery: Supports development of functional biodegradable polymer systems for drug-delivery and controlled-release research.
- Biomaterial Research: Supports development of functional biodegradable polymers, particles, coatings, composites, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions. Protect from moisture and excessive heat.
- Handling: Protect from moisture and excessive heat. Allow the material to equilibrate to room temperature before opening to minimize moisture condensation.
N3-Poly(ε-caprolactone) (PCL-N3), MW 15K provides a biodegradable PCL platform with terminal azide functionality for CuAAC and copper-free click chemistry and specifically supports bioconjugation, polymer functionalization, nanoparticle modification, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.