Representing the high‑molecular‑weight class of azide‑terminated poly(ε‑caprolactone), this 10 kDa polymer forms dense chain networks and elevated crystallinity that distinctly separate it from 2K, 3K and 5K lower‑molecular‑weight counterparts. Its terminal azide moiety enables reliable CuAAC click‑chemistry coupling with alkyne‑tagged biomolecules, generating chemically stable triazole linkages even within biologically relevant mixed‑phase environments. Extended polymer chains drastically slow hydrolytic breakdown, granting prolonged morphological persistence suitable for month‑scale biological observation. This material fills an important technical niche: it delivers superior particle stability for long‑circulating nanocarriers while stopping short of the multi‑month ultra‑slow degradation seen in 15K and 20K PCL‑N3 grades, making it ideal for long‑term nanoparticle‑oriented pre‑clinical studies.
Key Features: ‑ Long‑chain high‑crystallinity PCL backbone functionalized with terminal azide group, engineered for fabricating mechanically resilient click‑functionalized particulate systems ‑ Markedly retarded hydrolytic erosion rate, supporting weeks‑to‑month‑level structural retention for long‑duration in vitro and in‑vivo experimental workflows ‑ Strong intermolecular chain entanglement suppresses nanoparticle disassembly, reducing premature payload leakage under complex biological media conditions ‑ Excellent bio‑orthogonality; azide remains unreactive toward native amines, thiols and other biological moieties, ensuring high‑specificity CuAAC click ligation ‑ Well‑characterized azide end‑group fidelity via spectroscopic methods; low residual catalyst and monomer levels fit for advanced cell assays and small‑animal pre‑clinical evaluation
Applications: ‑ Construction of azide‑functionalized long‑circulating nanoparticles and micelles for sustained drug delivery and prolonged biodistribution profiling ‑ Click‑mediated surface modification of electrospun scaffolds for mid‑long‑term tissue‑engineering research without strict implant‑grade durability requirements ‑ Preparation of triazole‑bonded polymer‑protein and polymer‑peptide conjugates for long‑acting targeted delivery in small‑animal models ‑ Development of click‑modified biosensor coatings requiring extended structural stability under biological conditions ‑ Pre‑clinical formulation validation of long‑persistent particulate carriers as an intermediate step toward ultra‑high‑MW implant‑oriented PCL‑N3 platforms
Handling & Storage: Preserve lyophilized polymer powder at −20 °C under dry inert‑gas atmosphere. Although azide groups exhibit higher hydrolytic robustness compared to maleimide, repeated or long‑term moisture exposure will still gradually impair click‑chemistry reactivity. Place sealed vials in a desiccator and allow complete thermal equilibration to room temperature before opening to avoid water condensation on polymer solids. Prepare working solutions using anhydrous organic solvents right before experimental use; do not store dissolved polymer solutions over extended time periods. For laboratory research purposes only; not validated for human clinical application.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.