N-(Mal-PEG6)-N-bis(PEG7-TCO)
This product is a multifunctional PEG linker featuring a maleimide group for thiol conjugation and two trans-cyclooctene (TCO) groups for rapid tetrazine click chemistry. The PEG6 and PEG7 spacers specifically provide hydrophilicity, flexibility, and reduced steric hindrance, making it a powerful tool for orthogonal and multifunctional bioconjugation.
Key Features and Benefits:
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Maleimide Group: Reacts selectively with thiol groups in proteins and peptides.
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Dual TCO Groups: Enable fast, copper-free IEDDA click chemistry with tetrazines.
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PEG6/PEG7 Spacers: Provide solubility, spacing, and flexibility for conjugation.
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High Purity: Ensures reproducibility in advanced bioconjugation workflows.
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Orthogonal Reactivity: Combines thiol coupling and TCO–tetrazine click chemistry.
Applications:
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Bioconjugation: Enables multifunctional labeling of proteins, peptides, and antibodies.
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Antibody–Drug Conjugates (ADCs): Supports precise linker–payload assembly.
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Drug Delivery: Facilitates targeted delivery with orthogonal reactivity.
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Surface Modification: Functionalizes nanoparticles, hydrogels, or biomaterials.
Storage and Handling:
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Storage: Store at –20 °C, protected from light and moisture.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to maintain maleimide and TCO reactivity.
This product combines thiol-specific conjugation with dual TCO handles, making it especially ideal for multifunctional, orthogonal bioconjugation and drug delivery strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
