Mono-sulfone Benzoic Acid
This high-purity small-molecule linker features a mono-sulfone group for selective thiol–Michael addition and a benzoic acid moiety for amide bond formation with amines. Its dual reactivity enables stable thioether linkages and versatile coupling, making it especially valuable in protein modification, bioconjugation, and drug delivery applications in both aqueous and organic systems.
Key Features and Benefits
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Mono-sulfone Group – Reacts selectively with thiols to form stable thioether bonds.
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Benzoic Acid Moiety – Enables amide coupling with primary or secondary amines.
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Dual Reactivity – Supports orthogonal, sequential conjugation strategies.
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Versatile Compatibility – Suitable for aqueous and organic reaction conditions.
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High Purity – Ensures reliable and reproducible results in sensitive workflows.
Applications
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Protein and peptide modification
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Antibody–drug conjugate (ADC) linker chemistry
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Bioconjugation and labeling strategies
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Targeted drug delivery systems
Storage and Handling
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Storage: Store at –20 °C, dry, and protected from light
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Handling: Use anhydrous solvents; avoid prolonged exposure to moisture to maintain reactivity
This product is a high-purity bifunctional linker with a mono-sulfone for thiol coupling and amide formation, especially ideal for stable, orthogonal bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.