Bis-sulfone-Acid is a bis-alkylating labeling reagent that is selective for the cysteine sulfur atoms from a native disulfide. Bis-alkylating reagents undergo bis-alkylation to conjugate both thiols derived from the two cysteine residues of a reduced native disulfide bond such as the interchain disulfide bonds of an antibody. The reaction results in covalent rebridging of the disulfide bond via a three carbon bridge leaving the protein structurally intact.
The covalent, site-specific conjugation of PEG to a polyhistidine tag (His-tag) on a protein with bis-alkylating reagents was also reported in literature (see Selected References section).
Axispharm offers 3000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
Storage condition: -20 ° C
Shipping: Ambient Temperature
|AP12608||Desthiobiotin NHS Ester||311.34||≥95%||Pricing|
Desthiobiotin NHS Ester
|AP12697||DBCO-STP Ester||583.49||≥95% (HPLC)||Pricing|
|AP12681||TCO-NHS Ester (axial)||267.28||≥95% (HPLC)||Pricing|
TCO-NHS Ester (axial)
|AP12594||Bis-sulfone Amine||593.15 (HCl salt)||≥95% (HPLC)||Pricing|