Methyltetrazine-PEG8-NHS ester
This product is a heterobifunctional linker featuring a methyltetrazine group for ultrafast tetrazine ligation and an NHS ester for efficient amine coupling. The PEG8 spacer provides solubility, flexibility, and moderate spacing, making it especially useful for ADC development, probe design, and multifunctional bioconjugation.
Key Features and Benefits:
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Methyltetrazine Group: Enables rapid, copper-free IEDDA click chemistry with TCO.
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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PEG8 Spacer: Provides hydrophilicity, solubility, and steric accessibility.
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Dual Reactivity: Combines bioorthogonal and amine-targeted chemistry.
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High Purity: Ensures reproducibility in sensitive workflows.
Applications:
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ADC Development: Provides PEGylated linkers for targeted drug conjugates.
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Probe Development: Builds tetrazine-functionalized probes for imaging and diagnostics.
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Bioconjugation: Supports orthogonal and multifunctional conjugation strategies.
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Drug Delivery: Enhances solubility and stability of therapeutic conjugates.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); prepare fresh solutions to minimize NHS hydrolysis.
This product combines ultrafast tetrazine ligation with amine-reactive chemistry in a PEG8 scaffold, specifically offering solubility and dual functionality for advanced conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
