Methyltetrazine-PEG8-acid
This product is a heterobifunctional linker featuring a methyltetrazine group for rapid, copper-free IEDDA ligation with TCO and a terminal carboxylic acid for amide coupling. The PEG8 spacer specifically enhances solubility, flexibility, and steric separation, making it ideal for probe design, ADCs, and drug delivery.
Key Features and Benefits:
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Methyltetrazine Group: Supports ultrafast bioorthogonal ligation with TCO.
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Carboxylic Acid: Couples with amines to form stable amide bonds.
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PEG8 Spacer: Provides solubility, hydrophilicity, and extended spacing.
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Dual Functionality: Combines click-ready and conjugation handles.
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High Purity: Ensures reproducible results in advanced applications.
Applications:
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ADC Development: Provides PEGylated linkers for targeted release.
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Bioconjugation: Couples biomolecules through dual-reactive groups.
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Probe Development: Builds tetrazine-modified probes for imaging and diagnostics.
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Drug Delivery: Supports multifunctional conjugates with improved circulation.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged exposure to light.
This product combines bioorthogonal tetrazine reactivity with amine-coupling acid functionality in a PEG8 scaffold, specifically offering solubility and versatility for advanced conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.