Methyltetrazine-PEG4-Oxyamine is a heterobifunctional linker featuring methyltetrazine for bioorthogonal click chemistry and an oxyamine group for conjugation to aldehydes or ketones via oxime bond formation. The PEG4 spacer enhances solubility and reduces steric hindrance, facilitating efficient reactions.
Key Features
- Methyltetrazine Group
Enables rapid and selective IEDDA reactions with strained alkenes (e.g., trans-cyclooctene). - Oxyamine Group
Reacts specifically with aldehydes and ketones to form stable oxime bonds. - PEG4 Spacer
Improves water solubility and minimizes steric effects during conjugation.
Applications
- Bioconjugation
Ideal for linking biomolecules, such as proteins or peptides, containing aldehydes or ketones. - Drug Delivery Systems
Facilitates the conjugation of therapeutic molecules for targeted release. - Molecular Probes
Useful in designing dual-functional probes for imaging or diagnostics. - Material Science
Suitable for modifying surfaces and creating functional polymers.
Short Description
Methyltetrazine-PEG4-Oxyamine is a bifunctional linker with methyltetrazine for IEDDA reactions and oxyamine for aldehyde/ketone conjugation, ideal for bioconjugation, imaging, and drug delivery.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
