Methyltetrazine-PEG4-amine HCl salt
This product is a heterobifunctional PEG4 linker with a methyltetrazine for rapid inverse-electron-demand Diels–Alder (IEDDA) click chemistry and a primary amine provided as a hydrochloride salt for enhanced solubility and stability. The PEG4 spacer offers hydrophilicity and flexibility, making it especially useful for orthogonal bioconjugation, probe design, and therapeutic applications.
Key Features and Benefits:
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Methyltetrazine Group: Reacts rapidly with strained alkenes such as TCO and BCN.
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Amine Group (HCl Salt): Stable, water-soluble form that couples efficiently with carboxyls and NHS esters.
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PEG4 Spacer: Provides compact hydrophilic spacing and reduced steric hindrance.
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High Purity: Ensures reproducibility in bioconjugation and therapeutic workflows.
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Dual Reactivity: Supports orthogonal strategies combining IEDDA click chemistry and amide coupling.
Applications:
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Bioorthogonal Labeling: Enables ultrafast tetrazine–TCO ligation for in vitro and in vivo studies.
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Bioconjugation: Facilitates dual-functional labeling of proteins, peptides, and biomolecules.
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Probe Development: Useful in fluorescent, radiolabeled, or affinity probe synthesis.
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Drug Delivery: PEGylated linker improves solubility, circulation, and targeted delivery.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, light-protected container.
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Handling: Use aqueous buffers or anhydrous solvents (e.g., DMF, DMSO); avoid prolonged light exposure to preserve tetrazine reactivity.
This product combines ultrafast tetrazine click chemistry with amine reactivity in a compact PEG chain, making it an especially excellent reagent for advanced conjugation, probe development, and therapeutic applications.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
