Methyltetrazine-PEG4-acid
This product is a heterobifunctional linker composed of a methyltetrazine group, a PEG4 spacer, and a terminal carboxylic acid. The methyltetrazine enables ultrafast, copper-free click chemistry with trans-cyclooctene (TCO) via inverse electron-demand Diels–Alder (IEDDA) ligation, while the carboxyl group couples efficiently with amines or activated esters. The PEG4 spacer improves solubility, flexibility, and accessibility, making this reagent especially valuable for bioconjugation, probe design, and drug delivery.
Key Features and Benefits
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Methyltetrazine Group: Enables rapid, copper-free click ligation with TCO.
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Carboxylic Acid Group: Couples readily with amines for stable amide bond formation.
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PEG4 Spacer: Enhances solubility and reduces steric hindrance.
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Dual Reactivity: Combines bioorthogonal click chemistry with classical conjugation.
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High Purity: Produced to ≥95% purity for reliable performance.
Applications
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Bioconjugation: Links TCO-modified and amine-functionalized biomolecules.
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Protein and Antibody Labeling: Provides bioorthogonal handles for site-specific modifications.
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Probe Development: Builds dual-functional probes for imaging and diagnostics.
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Drug Delivery: Functions as a linker in targeted therapeutic systems.
Storage and Handling
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Prepare fresh solutions before use; avoid repeated freeze–thaw cycles.
This product integrates ultrafast bioorthogonal chemistry with carboxyl coupling in a PEG4 backbone, specifically offering a versatile tool for advanced conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
