Methyltetrazine-PEG24-NHS ester
This product is a heterobifunctional linker containing a methyltetrazine group for ultrafast IEDDA ligation with TCO and an NHS ester for amine coupling. The PEG24 spacer provides exceptional solubility, hydrophilicity, and long-chain flexibility, making it especially effective in bioorthogonal labeling, ADC development, and advanced bioconjugation.
Key Features and Benefits:
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Methyltetrazine Group: Enables rapid, copper-free click chemistry with TCO.
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NHS Ester: Couples efficiently with primary amines under mild conditions.
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PEG24 Spacer: Provides long, flexible spacing and excellent solubility.
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Dual Reactivity: Combines amine reactivity with bioorthogonal chemistry.
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High Purity: Ensures reproducibility in advanced applications.
Applications:
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ADC Development: Builds long-linker scaffolds for antibody–drug conjugates.
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Bioorthogonal Labeling: Enables ultrafast tetrazine ligation in vitro and in vivo.
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Probe Development: Creates multifunctional probes for imaging and diagnostics.
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Drug Delivery: Improves solubility and circulation of PEGylated conjugates.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid NHS ester hydrolysis.
This product combines ultrafast tetrazine reactivity with amine coupling in a PEG24 scaffold, specifically offering superior solubility and spacing for advanced conjugation workflows.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
