Methyltetrazine-PEG2-Maleimide (Methyltetrazine-PEG2-Mal) is a versatile, heterobifunctional linker combining a tetrazine group for bioorthogonal click chemistry and a maleimide group for thiol-specific conjugation, separated by a short PEG2 spacer for enhanced solubility and reduced steric hindrance.
Key Features
- Bioorthogonal Methyltetrazine
Enables fast, selective conjugation with strained alkenes (e.g., trans-cyclooctene) via inverse electron demand Diels-Alder (IEDDA) reactions. - Thiol-Specific Maleimide
Forms stable bonds with free thiol groups in proteins, peptides, or other biomolecules. - Hydrophilic PEG2 Spacer
Improves solubility in aqueous systems and minimizes steric hindrance for efficient reactions.
Applications
- Site-Specific Protein Labeling
Ideal for precise attachment of imaging probes, fluorophores, or drug molecules. - Crosslinking and Bioconjugation
Supports dual functionalization and creation of complex biomolecular assemblies. - Drug Delivery Systems
Enables development of targeted therapeutics through controlled conjugation strategies. - Surface and Material Functionalization
Useful for modifying nanoparticles, polymers, or hydrogels.
Advantages
This product combines bioorthogonal and thiol-reactive chemistries with a flexible, hydrophilic spacer, making it highly efficient for applications requiring precise, controlled bioconjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
