Methyltetrazine-PEG12-NHS ester
This product is a heterobifunctional linker with a methyltetrazine group for ultrafast IEDDA ligation and an NHS ester for efficient amine coupling. The PEG12 spacer enhances solubility, flexibility, and spacing, making it especially valuable for bioorthogonal labeling, probe development, and therapeutic conjugation.
Key Features and Benefits:
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Methyltetrazine Group: Supports rapid, catalyst-free click chemistry with TCOs.
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NHS Ester: Couples efficiently with primary amines to form stable amide bonds.
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PEG12 Spacer: Provides hydrophilicity, long spacing, and steric accessibility.
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Dual Reactivity: Combines amine coupling with bioorthogonal click chemistry.
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High Purity: Ensures reproducibility in sensitive bioconjugation workflows.
Applications:
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Bioorthogonal Labeling: Enables rapid, copper-free ligation with TCO-modified biomolecules.
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Bioconjugation: Links amine-containing proteins or peptides with tetrazine–TCO chemistry.
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Drug Delivery: PEGylated linker improves solubility and circulation properties.
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Probe Development: Builds imaging probes and targeted therapeutic scaffolds.
Storage and Handling:
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Storage: Store at –20 °C in a tightly sealed, light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO); avoid prolonged exposure to moisture.
This product combines rapid bioorthogonal chemistry with amine coupling in a long PEG scaffold, making it an especially versatile tool for conjugation and targeted probe design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
