Methyltetrazine-PEG12-acid
This product is a heterobifunctional linker containing a methyltetrazine group for rapid, copper-free IEDDA ligation with trans-cyclooctene (TCO) and a terminal carboxylic acid for amide coupling. The PEG12 spacer provides excellent solubility, flexibility, and spacing, making it especially effective for bioorthogonal labeling, ADC design, and drug delivery.
Key Features and Benefits:
-
Methyltetrazine Group: Enables ultrafast IEDDA click reactions with TCO.
-
Carboxylic Acid: Couples efficiently with amines via amide bond formation.
-
PEG12 Spacer: Improves solubility, hydrophilicity, and steric accessibility.
-
Dual Reactivity: Combines bioorthogonal and amine-reactive chemistry.
-
High Purity: Ensures reliable, reproducible results.
Applications:
-
Bioorthogonal Labeling: Supports rapid copper-free conjugation.
-
ADC Development: Provides long-chain PEG spacing for antibody–drug conjugates.
-
Probe Development: Builds methyltetrazine-functionalized probes for imaging and diagnostics.
-
Drug Delivery: Improves solubility and circulation of therapeutic conjugates.
Storage and Handling:
-
Storage: Store at –20 °C in a tightly sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents (e.g., DMF, DMSO); protect from premature hydrolysis.
This product combines ultrafast tetrazine ligation with amide chemistry in a PEG12 scaffold, specifically offering versatility for conjugation, drug delivery, and probe development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
