Methyltetrazine-acid
This product is a small-molecule building block containing a reactive methyltetrazine group and a terminal carboxylic acid. It specifically enables rapid inverse electron-demand Diels–Alder (IEDDA) reactions with trans-cyclooctene (TCO) and supports amide coupling for versatile bioconjugation.
Key Features and Benefits
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Methyltetrazine Group: Reacts rapidly with TCO in bioorthogonal IEDDA click chemistry.
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Carboxylic Acid: Couples efficiently with amines to form stable amide bonds.
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Compact Design: Provides minimal steric hindrance for conjugation.
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Bioorthogonal Reactivity: Performs selectively in complex biological environments.
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High Purity: Ensures reproducibility in bioconjugation workflows.
Applications
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Bioconjugation: Links TCO-modified biomolecules through rapid tetrazine chemistry.
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Probe Development: Builds click-enabled probes for imaging and diagnostics.
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Drug Delivery: Provides a scaffold for targeted therapeutic conjugates.
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Organic Synthesis: Serves as a versatile intermediate in linker design.
Storage and Handling
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Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
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Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates rapid click reactivity with carboxyl functionality, specifically offering a compact and efficient scaffold for conjugation and synthesis.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
