Mal-PEG6-acid
This product is a PEG linker containing a maleimide group, a PEG6 spacer, and a terminal carboxylic acid. It enables thiol-selective conjugation through the maleimide and amide coupling through the carboxyl group, making it especially versatile for bioconjugation.
Key Features and Benefits
-
Maleimide Group: Couples selectively with thiols to form stable thioether bonds.
-
Carboxylic Acid: Reacts with amines to generate stable amide linkages.
-
PEG6 Spacer: Provides solubility, flexibility, and reduced steric hindrance.
-
Dual Reactivity: Combines thiol chemistry with carboxyl conjugation.
-
High Purity: Ensures reproducible performance in sensitive workflows.
Applications
-
Bioconjugation: Links thiol-containing biomolecules with amine-reactive partners.
-
Probe Development: Builds multifunctional probes for imaging and diagnostics.
-
Drug Delivery: Provides PEG scaffolds with orthogonal conjugation handles.
-
Material Science: Functionalizes nanoparticles, polymers, and surfaces with dual reactivity.
Storage and Handling
-
Storage: Store at –20 °C in a sealed, light- and moisture-protected container.
-
Handling: Use anhydrous solvents such as DMF or DMSO; avoid prolonged exposure to moisture.
This product integrates thiol-reactive maleimide chemistry with carboxyl functionality in a PEG6 scaffold, specifically offering flexibility and solubility for advanced conjugation.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
