Mal-PEG36-NHS
Mal-PEG36-NHS is a dual-functional PEG linker designed for precision bioconjugation. It features a maleimide group for thiol-specific conjugation and an NHS (N-hydroxysuccinimide) ester for efficient coupling with primary amines. Its PEG36 chain enhances water solubility, flexibility, and minimizes steric hindrance, making it ideal for biological and chemical applications.
Key Features
- Functional Groups:
- Maleimide: Reacts specifically with thiol groups (-SH) to form stable thioether bonds.
- NHS Ester: Conjugates with primary amines, forming stable amide bonds.
- PEG Spacer:
- PEG36 provides enhanced solubility and biocompatibility.
- Long chain length reduces steric hindrance in complex conjugations.
- Biocompatibility:
- Non-toxic and suitable for in vitro and in vivo applications.
Applications
- Bioconjugation: Links peptides, proteins, or nucleic acids via thiol and amine chemistry.
- Drug Delivery: Serves as a linker to improve solubility and pharmacokinetics of drug conjugates.
- Nanotechnology: Functionalizes nanoparticles, biosensors, and surfaces for targeted labeling and modification.
- Chemical Biology: Enables precise and efficient conjugation in complex systems.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
