Mal-PEG3-acid
This product is a heterobifunctional linker featuring a maleimide group, a short PEG3 spacer, and a terminal carboxylic acid. The maleimide reacts selectively with thiols to form stable thioether bonds, while the carboxyl group couples efficiently with amines or activated esters. The PEG3 spacer improves solubility and flexibility while keeping the design compact, making this linker highly suitable for bioconjugation, drug delivery, and probe development.
Key Features and Benefits
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Maleimide Group: Selectively couples with thiols to form stable linkages.
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Carboxylic Acid Group: Reacts readily with amines for amide bond formation.
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PEG3 Spacer: Enhances solubility and reduces steric hindrance.
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Compact Design: Provides short but flexible spacing for efficient conjugation.
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High Purity: Produced to ≥95% purity for reproducibility.
Applications
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Bioconjugation: Links thiol- and amine-functionalized biomolecules.
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Antibody–Drug Conjugates (ADCs): Functions as a compact, bifunctional linker.
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Drug Delivery: Serves as a PEGylated intermediate for therapeutic conjugates.
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Probe Development: Builds multifunctional probes for imaging and diagnostics.
Storage and Handling
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Storage: Store at –20 °C in a sealed, desiccated container.
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Handling: Prepare fresh solutions before use; avoid repeated freeze–thaw cycles.
This product combines thiol reactivity and carboxyl coupling in a compact PEG3 scaffold, specifically offering a versatile tool for controlled conjugation and therapeutic design.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
