Mal-PEG-HZ, MW 20K (Maleimide-PEG-Hydrazide) contains two distinct functional groups, a maleimide group, and a hydrazide group (-NHNH2), attached to the ends of a PEG chain.
Mal-PEG-HZ, MW 20K (Maleimide-PEG-Hydrazide) has been extensively utilized in the development of various drug delivery systems. One of the most significant applications of this compound is in the synthesis of antibody-drug conjugates (ADCs). ADCs are a novel class of therapeutics that utilize the specificity of monoclonal antibodies to deliver cytotoxic agents directly to cancer cells, reducing systemic toxicity and improving therapeutic efficacy. Maleimide-PEG-Hydrazide can be used to conjugate a hydrazide-modified cytotoxic agent to a maleimide-modified antibody, forming a stable ADC with high specificity and potency.
In addition to its use in ADCs, Maleimide-PEG-Hydrazide has also been employed in the development of imaging agents, such as fluorescent probes and magnetic resonance imaging (MRI) contrast agents. Its unique chemical properties allow for the covalent attachment of imaging moieties, improving the sensitivity and specificity of diagnostic imaging.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.