Mal-CH2-Cyclohexylcarboxylhydrazide TFA (CAS: 181148-00-5, 359436-59-2)
Mal-CH2-Cyclohexylcarboxylhydrazide TFA acts as a versatile heterobifunctional linker for bioconjugation and PROTAC synthesis. Its maleimide group selectively reacts with thiol groups (-SH), forming stable thioether bonds, while the hydrazide group conjugates with aldehydes or ketones through hydrazone formation. The cyclohexyl ring structure enhances molecular stability and rigidity, while making it ideal for advanced drug development applications.
Key Features:
- Functional Groups:
- Maleimide: Reacts efficiently with thiol groups to form stable thioether bonds.
- Hydrazide: Forms hydrazone bonds with carbonyl-containing compounds like aldehydes and ketones.
- Structural Stability:
- The cyclohexyl ring provides rigidity, so molecular stability and pharmacokinetic performance is improved.
Applications:
- Bioconjugation:
- Mal-CH2-Cyclohexylcarboxylhydrazide TFA Links proteins, peptides, or other biomolecules by reacting with thiols and carbonyl groups.
- PROTAC Synthesis:
- Functions as a key linker in developing PROTAC molecules, facilitating targeted protein degradation.
Handling and Storage:
- Molecular Formula: C₁₄H₁₈F₃N₃O₅
- Molecular Weight: 365.31 g/mol
- Storage: Store in a cool, dry place, away from light and moisture to preserve stability.
In summary, the product enhances molecular research through efficient bioconjugation and targeted drug development. Its dual reactivity and structural rigidity make it indispensable for applications in chemical biology, proteomics, and pharmaceutical development.
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