HyNic PEG2 BCN (CAS: 1507370-54-8) is a bifunctional linker with a 6-hydrazinonicotinamide (HyNic) group and a bicyclo[6.1.0]nonyne (BCN) group connected by a PEG2 spacer. The HyNic group forms stable hydrazone bonds with carbonyl-containing biomolecules, while the BCN group enables copper-free click chemistry with azides through strain-promoted azide-alkyne cycloaddition (SPAAC). The PEG2 spacer improves solubility and flexibility in aqueous environments.
Key Features:
- Functional Groups: HyNic for hydrazone bond formation and BCN for copper-free click chemistry.
- Molecular Formula: C₂₆H₃₇N₅O₅
- Molecular Weight: 499.60 g/mol
- Purity: ≥95%
HyNic PEG2 BCN Applications:
- Bioconjugation: Attaches biomolecules through hydrazone bonding and click chemistry with azides.
- Antibody-Drug Conjugates (ADCs): Acts as a stable linker for drug-antibody conjugation.
- Surface Functionalization: Enables immobilization of biomolecules on surfaces for biosensors and bioassays.
This linker ensures precise and efficient molecular assembly, making it valuable for targeted drug delivery, diagnostics, and chemical biology research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
