Folate-PEG1-Mal is a small molecule linker that contains several functional groups, including a folate group, a PEG (polyethylene glycol) chain, and a maleimide group.
The folate group is a type of vitamin B that binds to folate receptors, which are overexpressed in some cancer cells. By attaching folate to the linker, it can selectively target cancer cells that overexpress these receptors, improving the specificity and efficacy of treatment.
The PEG chain in Folate-PEG1-Mal improves the solubility and biocompatibility of the linker, reducing its immunogenicity and toxicity, and enabling it to circulate in the bloodstream for longer periods of time.
The maleimide group in Folate-PEG1-Mal is a reactive functional group that can react with thiol groups, forming a stable thioether bond. This property enables the linker to conjugate with thiol-containing molecules, such as cysteine residues on proteins, enabling the delivery of drugs or other molecules to the targeted cells.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.