endo-BCN-PEG8-acid
This product is a heterobifunctional linker containing an endo-bicyclononyne (endo-BCN) group for rapid, copper-free SPAAC click chemistry and a terminal carboxylic acid for amide coupling. The PEG8 spacer enhances solubility, flexibility, and steric accessibility, making it especially effective in bioconjugation, probe development, and drug delivery.
Key Features and Benefits:
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endo-BCN Group: Enables fast, catalyst-free click reactions with azides.
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Carboxylic Acid: Couples efficiently with amines to form stable amide bonds.
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PEG8 Spacer: Provides solubility and moderate chain length for flexible conjugation.
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Dual Reactivity: Combines bioorthogonal SPAAC with amide chemistry.
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High Purity: Ensures reproducibility in sensitive applications.
Applications:
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Bioconjugation: Links azide- and amine-containing biomolecules.
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Probe Development: Creates BCN-modified probes for imaging and diagnostics.
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Drug Delivery: Provides PEGylated scaffolds with enhanced solubility and stability.
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Material Science: Functionalizes surfaces, polymers, and nanoparticles.
Storage and Handling:
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Storage: Store at –20 °C in a sealed, moisture- and light-protected container.
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Handling: Use anhydrous solvents (e.g., DMF, DMSO) to preserve reactivity.
This product combines fast SPAAC reactivity with carboxyl coupling in a PEG8 scaffold, specifically offering solubility, spacing, and versatility for advanced conjugation strategies.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
