endo-BCN-OH (CAS: 1263166-90-0) is a strained cyclooctyne derivative featuring a primary alcohol group. This structure enables efficient, copper-free click chemistry reactions with azides, forming stable triazole linkages without the need for a copper catalyst.
Key Features:
- Strained Cyclooctyne: Facilitates rapid and selective strain-promoted alkyne-azide cycloaddition (SPAAC) reactions.
- Primary Alcohol Group: Allows for further functionalization or conjugation to other molecules.
- Copper-Free Click Chemistry: Enables bioconjugation in sensitive biological systems without cytotoxic copper catalysts.
Applications:
- Bioconjugation: Attaching biomolecules such as proteins, peptides, or nucleic acids to azide-functionalized counterparts.
- Material Science: Functionalizing surfaces or polymers with azide groups for advanced material design.
- Drug Delivery: Developing targeted delivery systems by conjugating therapeutic agents to azide-modified carriers.
Handling and Storage:
- Storage Conditions: Store at -20°C, protected from light and moisture.
- Stability: Stable under recommended storage conditions; handle under inert atmosphere to prevent degradation.
endo-BCN-OH is a versatile tool for bioorthogonal chemistry, enabling efficient and selective conjugation in various research and development applications.
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