Emideltide (acetate)
Emideltide (acetate) CAS：62568-57-4, also known as Delta Sleep-Inducing Peptide (DSIP) acetate, is a synthetic nonapeptide with sedative, sleep-modulating, neuroprotective, and stress-regulating properties. It is widely used in preclinical research for sleep regulation, stress response modulation, and central nervous system protection.
Description
Emideltide (acetate) is a synthetic acetate salt form of the endogenous neuropeptide DSIP, composed of the amino acid sequence Trp‑Ala‑Gly‑Gly‑Asp‑Ala‑Ser‑Gly‑Glu. It acts on the central nervous system to regulate sleep architecture, enhance delta‑wave (slow‑wave) sleep, modulate neurotransmitter levels (e.g., serotonin, dopamine), and normalize stress‑related hormonal responses. The acetate formulation improves water solubility, stability, and bioavailability, making it suitable for in vitro and in vivo research applications.
Key Features
- Potent sleep‑modulating peptide that increases EEG delta activity and promotes non‑rapid eye movement (NREM) sleep.
- Strong stress‑reducing and anxiolytic effects, helping normalize hypothalamic‑pituitary‑adrenal (HPA) axis function.
- Neuroprotective activity against oxidative stress, ischemia, and neuronal damage.
- Modulates circadian rhythms and supports recovery from sleep disturbances.
- Stable acetate salt with excellent water solubility (PBS: 10 mg/mL) and high purity for reliable research results.
- Low molecular weight (848.8 g/mol + x·60 g/mol) enabling rapid tissue distribution in preclinical models.
Preclinical Research Applications
- Sleep disorder research: insomnia, sleep fragmentation, and circadian rhythm dysregulation.
- Stress and anxiety modulation in animal models of chronic stress and emotional distress.
- Neuroprotection in cerebral ischemia, traumatic brain injury, and neurodegenerative models.
- Studies on hormonal regulation and HPA axis function under stress conditions.
- Investigation of neurotransmitter balance and central nervous system adaptability.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
