DSPE (1,2-Distearoyl-sn-glycero-3-phosphoethanolamine) is an amphiphilic phospholipid containing two saturated C18 stearoyl chains and a phosphoethanolamine headgroup, while its structure supports lipid membrane formation, liposome formulation, lipid nanoparticle research, and synthesis of functional lipid conjugates.
Key Features and Benefits
- Phospholipid Structure: DSPE combines a hydrophilic phosphoethanolamine headgroup with two hydrophobic stearoyl chains.
- C18 Lipid Chains: Two saturated C18 chains provide a hydrophobic domain for lipid membrane and assembly research.
- Phosphoethanolamine Headgroup: The ethanolamine functionality specifically provides a primary amine for compatible chemical modification and conjugation.
- Amphiphilic Character: The hydrophilic headgroup and hydrophobic tails specifically promote organization within lipid bilayers and related assemblies.
- Lipid Membrane Formation: DSPE can incorporate into phospholipid membranes, liposomes, and other lipid-based structures.
- Functionalization Capability: The primary amine provides a reactive site for preparing modified DSPE derivatives through compatible coupling chemistry.
- Lipid Conjugate Precursor: DSPE provides a useful starting material for synthesizing PEGylated and other functional phospholipids.
- Versatile Lipid Platform: Its defined phospholipid structure specifically supports formulation, conjugation, and biomaterial research.
Applications
- Liposome Research: DSPE supports formulation and investigation of phospholipid vesicles and membrane systems.
- Lipid Nanoparticle Research: Researchers can incorporate DSPE into experimental lipid nanoparticle formulations.
- Lipid Bilayer Research: Supports studies of phospholipid organization, membrane structure, and lipid interactions.
- Lipid Conjugate Synthesis: The ethanolamine group provides a functional site for preparing modified DSPE derivatives.
- PEG-Lipid Synthesis: DSPE can serve as a lipid precursor for synthesizing DSPE-PEG and functional DSPE-PEG conjugates.
- Nanoparticle Formulation: Supports development of lipid-containing nanoparticles and related self-assembled systems.
- Drug Delivery Research: Provides a phospholipid component for experimental lipid-based delivery systems.
- Biomaterial Research: Supports development and investigation of phospholipid-containing biomaterials.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
DSPE (1,2-Distearoyl-sn-glycero-3-phosphoethanolamine) combines two saturated C18 lipid chains with a functional phosphoethanolamine headgroup and specifically provides a versatile platform for lipid formulation, membrane research, conjugation, and functional lipid development.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
