DOPE-Azide (DOPE-N3) is an azide-functionalized phospholipid containing a hydrophobic DOPE lipid domain and reactive azide (-N₃) functionality, while the azide group supports bioorthogonal click chemistry for bioconjugation, lipid functionalization, nanoparticle modification, and biomaterial research.
Key Features and Benefits
- Azide-Functionalized Phospholipid: DOPE-Azide (DOPE-N3) combines the membrane-forming properties of DOPE with click-reactive azide functionality.
- DOPE Lipid Structure: DOPE contains two unsaturated oleoyl C18 chains and a phosphoethanolamine-based lipid structure.
- Azide Functionality: The azide (-N₃) group specifically provides a bioorthogonal reactive site for selective chemical conjugation.
- CuAAC Click Chemistry: The azide reacts with terminal alkynes through copper-catalyzed azide-alkyne cycloaddition.
- SPAAC Click Chemistry: The azide reacts with strained cyclooctynes, such as DBCO, without requiring a copper catalyst.
- Lipid Membrane Incorporation: The hydrophobic lipid chains specifically support incorporation into compatible lipid membranes and assemblies.
- Bioconjugation Capability: Azide chemistry enables attachment of compatible ligands, probes, biomolecules, and functional groups.
- Functional Lipid Platform: DOPE and azide functionality provide an especially versatile platform for click-reactive lipid research.
Applications
- Click Chemistry: DOPE-Azide (DOPE-N3) supports CuAAC and SPAAC reactions with compatible alkyne and cyclooctyne compounds.
- Bioconjugation: The azide functionality enables attachment of compatible biomolecules, ligands, and molecular probes.
- Lipid Nanoparticle Research: Supports incorporation of click-reactive lipid functionality into experimental lipid nanoparticle systems.
- Liposome Research: Enables preparation and functionalization of azide-containing liposomes and related lipid assemblies.
- Ligand Conjugation: Supports attachment of alkyne- or cyclooctyne-functionalized ligands through click chemistry.
- Nanoparticle Functionalization: Provides azide functionality for modification of compatible lipid-containing nanoparticle systems.
- Membrane Research: Supports studies involving functionalized phospholipid membranes and lipid assemblies.
- Biomaterial Research: Enables development of click-reactive lipid materials and functional biomaterial systems.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under dry conditions.
- Handling: Protect from moisture, excessive heat, and prolonged exposure to air. Allow the material to reach room temperature before opening to minimize condensation.
DOPE-Azide (DOPE-N3) combines an unsaturated DOPE lipid structure with click-reactive azide functionality and specifically supports CuAAC, SPAAC, lipid functionalization, bioconjugation, nanoparticle modification, and biomaterial research.
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