DSPE-Aldehyde (Aldehyde-Functionalized DSPE) is a reactive phospholipid featuring a hydrophobic DSPE lipid anchor and aldehyde functionality. The aldehyde group supports conjugation with primary amines, hydrazides, and aminooxy-containing molecules for lipid and surface functionalization.
Key Features and Benefits
- Aldehyde-Functionalized Phospholipid: DSPE-Aldehyde provides reactive aldehyde functionality for conjugation and material modification.
- DSPE Lipid Anchor: DSPE contains two saturated C18 stearoyl chains that specifically support incorporation into compatible lipid membranes and assemblies.
- Aldehyde Functionality: The aldehyde group provides a reactive site for coupling with compatible nucleophilic functional groups.
- Amine-Reactive Chemistry: Aldehydes react with primary amines to form imine intermediates under suitable conditions.
- Reductive Amination: Aldehyde-amine reactions can undergo subsequent reduction to produce more stable covalent linkages.
- Hydrazide and Aminooxy Coupling: Aldehyde groups also support conjugation with compatible hydrazide and aminooxy-functionalized molecules.
- Amphiphilic Character: The DSPE structure specifically supports incorporation into compatible liposomes, lipid nanoparticles, and membrane systems.
- Functional Lipid Platform: The combination of a DSPE anchor and aldehyde specifically supports diverse bioconjugation and biomaterial applications.
Applications
- Bioconjugation: DSPE-Aldehyde (Aldehyde-Functionalized DSPE) supports conjugation with compatible amine, hydrazide, and aminooxy-containing molecules.
- Reductive Amination: Provides aldehyde functionality for amine coupling followed by reduction to form stable conjugates.
- Ligand Conjugation: Supports attachment of compatible peptides, proteins, probes, and other functional molecules.
- Liposome Functionalization: Enables incorporation of aldehyde-functionalized phospholipids into compatible liposome systems.
- Lipid Nanoparticle Research: Provides a reactive lipid component for experimental lipid nanoparticle formulations.
- Nanoparticle Functionalization: Supports presentation of aldehyde groups on compatible lipid-containing nanoparticles.
- Surface Modification: Provides reactive aldehyde functionality for modification of compatible lipid and material interfaces.
- Biomaterial Research: Supports development of functional lipid conjugates, assemblies, nanoparticles, and biomaterial systems.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Minimize prolonged exposure to conditions that may oxidize or otherwise alter the aldehyde functionality.
DSPE-Aldehyde (Aldehyde-Functionalized DSPE) combines a hydrophobic DSPE lipid anchor with reactive aldehyde functionality and specifically provides a versatile platform for reductive amination, bioconjugation, lipid functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.