DSPE-Polysarcosine, DP 10 is an amphiphilic lipid-polymer conjugate featuring a hydrophobic DSPE lipid anchor and hydrophilic polysarcosine (PSar) chain. The polysarcosine segment contains approximately 10 sarcosine repeat units, specifically providing a compact hydrophilic polymer interface for lipid-based systems.
Key Features and Benefits
- Amphiphilic Structure: DSPE-Polysarcosine combines a hydrophobic phospholipid anchor with a hydrophilic polysarcosine chain.
- Polysarcosine DP 10: The PSar segment contains approximately 10 sarcosine repeat units, providing a short and compact hydrophilic polymer chain.
- DSPE Lipid Anchor: DSPE contains two saturated C18 stearoyl chains that specifically support incorporation into lipid membranes and assemblies.
- Hydrophilic Polysarcosine: PSar provides a hydrophilic polymer segment for modifying lipid and nanoparticle interfaces.
- PEG Alternative: Polysarcosine provides a non-PEG hydrophilic polymer option specifically for lipid surface modification and formulation research.
- Lipid Membrane Incorporation: The DSPE anchor specifically supports incorporation into compatible liposomes, lipid nanoparticles, and lipid assemblies.
- Surface Modification: The PSar chain can provide a compact hydrophilic polymer layer on compatible lipid-based surfaces.
- Versatile Lipid-Polymer Platform: The combination of DSPE and PSar specifically supports lipid formulation and biomaterial research.
Applications
- Lipid Nanoparticle Research: DSPE-Polysarcosine, DP 10 supports research involving PSar-modified lipid nanoparticle systems.
- Liposome Research: Supports preparation and investigation of polysarcosine-containing liposomes and lipid assemblies.
- Polysarcosine Modification: Provides a lipid-anchored PSar chain for studying hydrophilic polymer interfaces.
- PEG-Alternative Research: Supports comparative research involving polysarcosine and conventional PEG-based lipid systems.
- Nanoparticle Formulation: Enables incorporation of a compact hydrophilic PSar component into compatible lipid-based nanoparticle formulations.
- Lipid Assembly Research: Supports studies of amphiphilic lipid-polymer organization and membrane incorporation.
- Surface Modification: Provides a hydrophilic polysarcosine layer for compatible lipid and material surfaces.
- Biomaterial Research: Supports development of polysarcosine-containing lipid-polymer materials and nanoscale systems.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
DSPE-Polysarcosine, DP 10 combines a DSPE lipid anchor with a compact polysarcosine chain of approximately 10 repeat units and specifically provides a non-PEG lipid-polymer platform for nanoparticles, liposomes, surface modification, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
