DSPE-Polysarcosine (DSPE-pSar) is a lipid-polypeptide conjugate based on the endogenous amino acid sarcosine (N-methylated glycine), which is compatible with polyethylene glycol (PEG) lipid-based systems. Compared with polysarcosine, polysarcosine has been shown to have higher protein secretion and lower immune stimulation response. DSPE-Polysarcosine can be used in lipid formulations to generate lipid nanoparticles (LNPs) for therapeutic applications of messenger RNA.
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