DSPE-PEG-OPSS, MW 5K is an amphiphilic phospholipid-PEG conjugate containing a terminal orthopyridyl disulfide (OPSS) group and specifically combines a hydrophobic DSPE lipid anchor with hydrophilic 5K PEG and thiol-reactive functionality for conjugation, lipid assembly, and biomaterial research.
Key Features and Benefits
- Amphiphilic Structure: DSPE-PEG-OPSS combines hydrophobic DSPE with hydrophilic PEG in one functional conjugate.
- PEG MW 5K: The 5K PEG segment provides a hydrophilic spacer between the lipid anchor and reactive OPSS group.
- DSPE Lipid Anchor: The phospholipid segment supports incorporation into lipid membranes, liposomes, and compatible nanostructures.
- OPSS Functionality: The terminal orthopyridyl disulfide group specifically provides a reactive site for coupling with thiol-containing molecules.
- Thiol-Reactive Chemistry: OPSS reacts with free thiols specifically through disulfide exchange to form disulfide-linked conjugates.
- Cleavable Disulfide Linkage: The resulting disulfide bond can undergo cleavage under suitable reducing conditions.
- PEGylated Lipid Platform: The PEG segment specifically supports development of functional PEG-containing lipid assemblies and nanoparticle surfaces.
- Functional Conjugation Platform: Combines lipid anchoring, PEG spacing, and thiol-reactive functionality within one material.
Applications
- Thiol Conjugation: Researchers use DSPE-PEG-OPSS, MW 5K to conjugate thiol-containing molecules through disulfide exchange.
- Bioconjugation: Supports coupling with cysteine-containing peptides, proteins, and other thiol-functionalized molecules.
- Liposome Functionalization: Enables introduction of thiol-reactive functionality onto PEGylated liposome surfaces.
- Nanoparticle Functionalization: Supports surface modification of lipid-based and compatible nanoparticle systems.
- Lipid Assembly Research: Enables studies of functional PEG-lipid incorporation into membranes and nanoscale assemblies.
- Cleavable Conjugate Research: Supports development of disulfide-linked conjugates that respond to suitable reducing conditions.
- Surface Modification: Provides a PEG spacer and terminal OPSS group for thiol-mediated surface functionalization.
- Biomaterial Research: Supports development of functional lipid-polymer assemblies, conjugates, and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Minimize exposure to reducing agents that may cleave the disulfide group. Allow the material to reach room temperature before opening to minimize condensation.
DSPE-PEG-OPSS, MW 5K combines a DSPE lipid anchor, hydrophilic PEG spacer, and thiol-reactive OPSS functionality and specifically supports disulfide conjugation, liposome functionalization, nanoparticle modification, and functional biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
