DSPE-Hydrazone-mPEG, MW 2K

Core Properties

• Amphiphilicity: The hydrophobic DSPE segment forms the core of self-assembled nanostructures (liposomes, micelles, or nanoparticles) in aqueous solution, while the hydrophilic mPEG chain forms a stabilizing outer shell.
• pH Sensitivity: The hydrazone bond is stable at physiological pH (~7.4) but undergoes rapid hydrolysis in acidic environments (pH 5.0–6.0), such as the tumor microenvironment, endosomes, or lysosomes.
• Solubility: Soluble in organic solvents (chloroform, methanol, DMSO, DMF) and forms stable colloidal dispersions in water.
• Appearance: Typically a white to off-white powderCreative B….
• Purity: ≥95% (HPLC/NMR/MS).
• Storage: Store at -20°C, desiccated, for up to 1 yearCreative B….

Key Applications

1. Smart Drug Delivery: Used to construct pH-responsive nanocarriers for targeted cancer therapy. Drugs are released specifically in acidic tumor tissues, enhancing efficacy and reducing systemic toxicity.
2. Liposome & Nanoparticle Formulation: Serves as a key component in preparing stealth liposomes and polymeric nanoparticles for encapsulating hydrophobic drugs, proteins, or nucleic acids (siRNA, mRNA).
3. Bioconjugation: The hydrazone group enables covalent coupling to carbonyl-containing molecules (e.g., aldehydes/ketones on antibodies or targeting ligands) for active targeting.
4. Prolonged Circulation: The mPEG 2K chain minimizes opsonization and clearance by the mononuclear phagocyte system (MPS), extending blood circulation half-life.

Summary