DSPE-Hydrazone-mPEG, MW 5K is an amphiphilic phospholipid-PEG conjugate containing a hydrazone linkage between DSPE and methoxy PEG and specifically combines a hydrophobic phospholipid anchor with a hydrophilic 5K mPEG segment for lipid assembly, nanoparticle formulation, and stimuli-responsive biomaterial research.
Key Features and Benefits
- Amphiphilic Structure: DSPE-Hydrazone-mPEG combines hydrophobic DSPE with hydrophilic methoxy PEG in one functional conjugate.
- mPEG MW 5K: The 5K mPEG segment specifically provides a hydrophilic polymer chain for aqueous-facing interfaces and steric stabilization research.
- DSPE Lipid Anchor: The phospholipid segment specifically supports incorporation into lipid membranes, liposomes, and compatible nanostructures.
- Hydrazone Linkage: The hydrazone bond provides an acid-sensitive linkage that can undergo hydrolysis under suitable acidic conditions.
- pH-Responsive Properties: The hydrazone linkage supports research into pH-dependent cleavage and stimuli-responsive material behavior.
- PEGylated Lipid Platform: The mPEG segment specifically supports development of PEG-containing lipid assemblies and nanoparticle surfaces.
- Self-Assembly Capability: Its amphiphilic structure supports incorporation into liposomes, micelles, and other compatible nanoscale assemblies.
- Functional Biomaterial Platform: Combines lipid anchoring, PEG functionality, and a cleavable hydrazone linkage within one material.
Applications
- Liposome Research: Researchers use DSPE-Hydrazone-mPEG, MW 5K in PEGylated lipid membrane and liposome formulations.
- Nanoparticle Formulation: Supports development and surface modification of lipid-based and compatible polymeric nanoparticles.
- pH-Responsive Research: Enables investigation of acid-sensitive hydrazone cleavage and pH-dependent material behavior.
- Stimuli-Responsive Materials: Supports development of nanomaterials designed to respond to changes in environmental pH.
- Drug Delivery Research: Enables investigation of PEGylated lipid carriers and pH-responsive delivery systems.
- Lipid Assembly Research: Supports studies of lipid organization, self-assembly, and PEG-containing membrane systems.
- Biomaterial Research: Provides an amphiphilic platform for functional lipid-polymer assemblies and related biomaterials.
Storage and Handling
- Storage: Store at –20 °C in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Avoid prolonged exposure to acidic conditions when preservation of the hydrazone linkage is required. Allow the material to reach room temperature before opening to minimize condensation.
DSPE-Hydrazone-mPEG, MW 5K combines a DSPE lipid anchor, hydrophilic mPEG, and an acid-sensitive hydrazone linkage and specifically supports lipid assembly, nanoparticle formulation, pH-responsive systems, and functional biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
