DSPE-Biotin (Biotinylated DSPE) is a biotin-functionalized phospholipid featuring a hydrophobic DSPE lipid anchor and biotin functionality, while the biotin group supports high-affinity binding with avidin and streptavidin for affinity-based conjugation and lipid functionalization.
Key Features and Benefits
- Biotinylated Phospholipid: DSPE-Biotin (Biotinylated DSPE) provides biotin functionality for affinity-based binding and conjugation.
- DSPE Lipid Anchor: DSPE contains two saturated C18 stearoyl chains that support incorporation into compatible lipid membranes and assemblies.
- Biotin Functionality: The biotin group specifically provides a high-affinity recognition site for avidin, streptavidin, and related biotin-binding proteins.
- Biotin-Avidin Interaction: Biotin enables strong noncovalent binding with avidin and streptavidin for versatile affinity-based systems.
- Amphiphilic Character: The DSPE structure specifically supports incorporation into compatible liposomes, lipid nanoparticles, and membrane systems.
- Lipid Membrane Incorporation: The lipid anchor specifically enables presentation of biotin functionality within compatible lipid bilayers and assemblies.
- Surface Functionalization: DSPE-Biotin supports biotin presentation at lipid interfaces for affinity-based modification.
- Functional Lipid Platform: The combination of DSPE and biotin supports diverse conjugation, recognition, and biomaterial applications.
Applications
- Biotin-Avidin Binding: DSPE-Biotin (Biotinylated DSPE) supports high-affinity avidin- and streptavidin-based binding systems.
- Bioconjugation: Enables noncovalent attachment of compatible avidin- or streptavidin-functionalized biomolecules and probes.
- Ligand Attachment: Supports affinity-based attachment of compatible ligands through biotin-avidin or biotin-streptavidin interactions.
- Liposome Functionalization: Enables incorporation of biotinylated phospholipids into compatible liposome systems.
- Lipid Nanoparticle Research: Provides a biotin-functionalized lipid component for experimental lipid nanoparticle formulations.
- Nanoparticle Functionalization: Supports presentation of biotin on compatible lipid-containing nanoparticle surfaces.
- Surface Modification: Provides biotin functionality for affinity-based modification of compatible lipid and material interfaces.
- Biomaterial Research: Supports development of biotin-functionalized lipid assemblies, nanoparticles, and biomaterial systems.
Storage and Handling
- Storage: Store according to the product specification in a tightly sealed container under dry conditions.
- Handling: Protect from moisture and excessive heat. Allow the material to reach room temperature before opening to minimize condensation.
DSPE-Biotin (Biotinylated DSPE) combines a hydrophobic DSPE lipid anchor with biotin functionality and specifically provides a versatile platform for avidin-streptavidin binding, bioconjugation, lipid functionalization, and biomaterial research.
AxisPharm offers 5000+ PEG Linkers with high purity. Different kinds of PEG Reagents may be available by custom synthesis.
